Can you freeze azithromycin?

In this brief guide, we’ll address the query: “Can you freeze azithromycin?” Also, we’ll explore how azithromycin should be stored, what azithromycin is, what azithromycin is prescribed for, and what are the contraindications of azithromycin. 

Can you freeze azithromycin

No, freezing azithromycin is not recommended for any Formulation of azithromycin, be it tablets or suspension.

Freezing provides a long-term storage alternative but is contraindicated for azithromycin tablets, which come with a specific set of instructions for storage.

Freezing is also contraindicated for azithromycin suspensions, once prepared, they should be used in their entirety and any leftovers should be discarded after 10 days.

Below we’ll review a few basic guidelines users can follow to properly store their azithromycin, be it in the form of tablets or a suspension. 

How can I store azithromycin

Azithromycin tablets should be stored at room temperature (15°C to 25°C), away from high levels of humidity, heat, and direct sunlight. This means that storing them in the medicine cabinet within the washroom may not be ideal. 

They can be stored in a kitchen cabinet or on any other cool, dark, dry shelf where they are kept out of the reach of children and pets.

Azithromycin suspensions, on the other hand, may be kept in refrigeration for the duration of the treatment, between doses. 

However extended-release Azithromycin suspension (which is clearly stated by the manufacturer) should not be frozen or refrigerated. 

Users should not preserve azithromycin suspensions for longer than the indicated treatment, and they should discard leftovers following basic disposal procedures, such as disposing of remains with coffee grinds and throwing them in the garbage. 

What is azithromycin? 

Azithromycin is a wide-spectrum antibiotic that acts against various gram-positive, and gram-negative bacteria. It was first discovered in 1980, by a team of researchers in Croatia.

Often referred to as a Z pack, its prescribed dosage is once a day. 

Initially, Pfizer acquired exclusive distribution rights in Western Europe and the USA, and Pliva, the company that first discovered it, held a patent on Azithromycin until 2005. 

Since then, it has been available under various formulations, made and distributed by various pharmaceutical companies. 

It can be administered orally, intravenously, and in ophthalmic drops. As it’s an antibiotic, its sale requires a medical prescription. 

It is metabolized via liver function and can leach extensively into the tissue of the lungs, skin, cervix, and prostate. 

At a biological level, azithromycin antagonizes the protein synthesis of bacteria, by inhibiting the translation of mRNA into amino acid sequences. 

This specific mechanism of action, however, makes it especially susceptible to drug resistance, as it does not interfere with the synthesis of nucleic acids. 

What is azithromycin prescribed for? 

Azithromycin is prescribed for the treatment of various infections of bacterial nature. Specifically, it may be indicated for the treatment of infections in the airways, middle ear infections, skin infections, and some sexually transmitted diseases.

Some resources allude to the bacterial species and genera that are susceptible to Azithromycin. The corresponding database is constantly updated for medical personnel to consult as needed.  

What are the contraindications of azithromycin? 

Azithromycin should be used only when prescribed by a doctor, and ergo under medical supervision. 

Thus far, it has not been shown to have any adverse effects on gestating or lactating women, though should only be taken under medical supervision.

Azithromycin is contraindicated for patients with low blood levels of magnesium, potassium, liver disease, abnormal liver function, liver failure, brachycardia (slow heart rate), hearing loss, infections with Clostridium difficile, and others.  

Adverse reactions to azithromycin may include an upset stomach, abdominal pain, nausea, vomiting, diarrhea, and watery stools. 

People with heart disease should not take azithromycin, to reduce the risk of adverse reactions such as blurred vision, lightheadedness, weakness, tachycardia, chest pain, or any other abnormal symptoms. 

We urge our readers to always avoid self-medicating, and if they suspect they have an infection that azithromycin can treat, they should always consult with a general practitioner or specialist to see if it’s an adequate course of treatment. 

Responsible antibiotic use extends the useful life of antibiotic molecules and helps safeguard everyone’s safety. 


In this brief guide, we’ve addressed the query: “Can you freeze azithromycin?” Also, we’ve explored how azithromycin should be stored, what azithromycin is, what azithromycin is prescribed for, and what are the contraindications of azithromycin. 


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