Can you eat grapefruit when taking Xarelto?

In this article, we are going to answer the question: can you eat grapefruit when taking Xarelto, what is grapefruit, where you can find it, what is Xarelto, what is it for, and what side effects it may have. 

Can you eat grapefruit when taking Xarelto?

No, you should not eat grapefruit when taking Xarelto. Also, you should stay away from grapefruit juice, marmalade, or anything that may contain grapefruit. 

Grapefruit directly affects the quantity of Xarelto in the blood, so levels of the medications go too high and it may cause more side effects. One of the major complications is that it leads to uncontrolled bleeding. 

What is grapefruit?

Grapefruit is a citrus fruit that tastes bitter sweet to sour. It’s a very nutritious fruit with a lot of vitamins and minerals Especially Vitamin C.  The interior is segmented and varies in color from pale yellow to dark pink. 

Raw grapefruit is about 90% water and 8% carbohydrates. Grapefruit contains about 50% more citric acid than orange juice. It is perfect for making grapefruit desserts, juice, and grapefruit jam. 

1 cup, 230 g with juice

%DV base in a 2,000 calorie diet
CarbohydratesTotal Carbs 24.5 gDietary fiber 3.7 gSugars 15.8 g
Fats0.3 g
Protein 1.8 g 
Vitamin A2645 UI53%
Vitamin C71.8 mg120%
Folate29.9 g7%

Even if grapefruit is a delicious and nutritious fruit, you should try to stay away from it while taking Xarelto. Try some orange or mandarin juice instead. 

Where can I find grapefruit?

First, as the fruit itself or as grapefruit juice. In a study, it was found that 23 drinks had grapefruit juice without having it written on its label. So, be careful with those citrus juices you take. You can also find it in marmalade. 

What is Xarelto?

Xarelto is a prescription drug that works as a blood thinner used to prevent blood clots that form due to irregular heartbeats or after hip or knee replacement.

It is used in adults that have an irregular heartbeat or atrial fibrillation. When you have atrial fibrillation, part of the heart does not beat as it should. 

It’s part of the new generation of blood thinners that reduces the risk of complications when taking grapefruit but even though it reduces its risk, you should be careful to eat grapefruit when taking Xarelto. 

By taking Xarelto there is an increased risk of blood clots and increased risk of bleeding, bleeding can lead to serious health problems and death. If taken with other medications that increase the risk of bleeding, you need to be cautious.

Other medications that include risk of bleeding are

  • Aspirin
  • NSAIDs
  • Warfarin sodium
  • Medicines that contain heparin
  • Clopidogrel
  • SSRIs or SNRIs
  • Other medicines to prevent or treat blood clots 

There have been many reports from the FDA from people taking Xarelto that report bleeding problems with or without grapefruit. 

What happens if you eat grapefruit when taking Xarelto?

Rivaroxaban (Xarelto) is metabolized by enzymes in the intestine. Grapefruit and other fruits of the same family have ​​furanocoumarins which prevent P450 from working normally which leads to an increase in blood levels of some medications. 

This blood level of medication can increase so much that it can be dangerous. Because of this, grapefruit can increase and worsen some side effects of the drug. 

If you eat grapefruit you can experience immediate bleeding from the gum, nose, unusual bruising, and dark stool. 

What are the side effects of Xarelto?

Xarelto as other drugs have side effects that can be worsened with grapefruit or grapefruit juice. 

  • Major bleeding events
  • Fainting
  • Itching
  • Bruising
  • Pain in arms and legs
  • Muscle pain
  • Muscle spasms

How can I replace grapefruit?

Because grapefruit has many interactions with medications. Here is a list of some fruits you can use instead of grapefruit. 

  • Orange
  • Mango
  • Peach
  • Pineapple

If you are on the military diet, a diet that specifically includes you eating grapefruit, here is a link for swaps. 


In this article, we answered the question: can you eat grapefruit when taking Xarelto, what is grapefruit and where you can find it, what is Xarelto, what is it for, and what side effects it may have. 


Hi, I am Charlotte, I love cooking and in my previous life, I was a chef. I bring some of my experience to the recipes on this hub and answer your food questions.