Can you eat grapefruit when taking Eliquis?

In this article, we are going to answer the question if you can eat grapefruit when taking Eliquis, what is Eliquis, what is grapefruit, what are the side effects of Eliquis, and where you can find grapefruit.

Can you eat grapefruit when taking Eliquis?

No, you can’t eat grapefruit when taking Eliquis or Apixaban (generic name). Eliquis is used to prevent serious blood clots from forming due to a certain irregular heartbeat or after hip/knee replacement. 

You should avoid grapefruit or grapefruit juice because it can change how the medicine works. The risk of side effects is higher if you take grapefruit or grapefruit juice when taking Eliquis. 

What is grapefruit?

Grapefruit is a citrus fruit that tastes bitter sweet to sour. Grapefruit is a hybrid that was created back in time, in Barbados, by an accidental cross between sweet orange and pomelo. 

It’s a very nutritious fruit with a lot of vitamins and minerals especially, Vitamin C.  The interior is segmented and varies in color from pale yellow to dark pink. It is known as one of the healthiest citrus fruits you can eat. 

It has been shown to have antibacterial, antiviral, antimicrobial, and antifungal effects that should not be taken with antibiotics. 

1 cup, 230 g with juice

%DV based in a 2,000 calories diet
CarbohydratesTotal Carbs 24.5 gDietary fiber 3.7 gSugars 15.8 g
Fats0.3 g
Protein 1.8 g 
Vitamin A2645 UI53%
Vitamin C71.8 mg120%
Folate29.9 g7%

Grapefruit have some powerful health benefits, even with these health benefits you should not eat it or drink it of taking Eliquis

  • Help boost immune system
  • May help with weight loss
  • May help prevent insulin resistance and diabetes
  • May improve heart health
  • High in antioxidant
  • Reduce the risk of kidney stones 

Grapefruit has interactions with more than just Eliquis, you need to be careful with 

  • immunosuppressants
  • benzodiazepines
  • most calcium channel blockers
  • indinavir
  • carbamazepine
  • some statins

What is Eliquis?

Eliquis or Apixaban (generic name) is a medication used to block certain coagulation substances in the blood. It is used as a prophylaxis treatment to reduce the risk of stroke with atrial fibrillation and as postoperative prophylaxis for deep vein thrombosis or DVT. 

It is considered an anticoagulant or a blood thinner. Eliquis is used as an alternative treatment to warfarin and does not require any monitoring by a blood test. It has fewer interactions with other medications than warfarin.

What happens if I eat grapefruit when taking Eliquis?

Medications are processed by our liver by an enzyme called cytochrome P450 (CYPs). This enzyme breaks down medication reducing blood levels of them. 

Grapefruit and other fruits of the same family have ​​furanocoumarins which prevent P450 from working normally which leads to an increase in blood levels of some medications. 

This blood level of medication can increase so much that it can be dangerous. Because of this, grapefruit can increase and worsen some side effects of the drug. 

In some studies, apart from P450 inhibition, it has been shown that it also inhibits OATP (organic anion transporting peptide) that as its name says, is a transporter for some drugs. So, other drugs can have decreased effects. 

If you take grapefruit in any presentation it can lead to hemorrhage and worsen side effects. 

What is the side effect of Eliquis?

People who eat or drink grapefruit with Eliquis have more risk of suffering side effects from the medication such as

  • Hives
  • Chest pain
  • Feeling light-headed
  • Swelling of your face, lips, tongue, or throat
  • Wheezing
  • Difficult breathing 
  • Easy bruising
  • Headache
  • Dizziness
  • Bleeding that will not stop
  • Loss of bladder or bowel control
  • Back pain
  • Numbness or muscle weakness

Here is a link where you can find more information about Eliquis

Where can I find grapefruit?

First, as the fruit itself or as grapefruit juice. In a study, it was found that 23 drinks had grapefruit juice without having it written on its label. So, be careful with those citrus juices you take. You can also find it in marmalade and some desserts. 


In this article, we answered the question if you can eat grapefruit when taking Eliquis, what is Eliquis, what is grapefruit, what are the side effects of Eliquis, and where you can find grapefruit.


Hi, I am Charlotte, I love cooking and in my previous life, I was a chef. I bring some of my experience to the recipes on this hub and answer your food questions.