Can I mix coffee and advil?

In this short article, we will answer the question “Can I mix Advil and coffee?”. In addition, we will discuss possible interactions between caffeine and paracetamol and sleeping pills. Finally, we will discuss if you can take a pill with coffee.

Can I mix coffee and advil?

Yes, you can mix advil and coffee. The combination of tablets containing 200 mg of Advil plus 100mg of caffeine reduces pain significantly, without any adverse effects. The combination of Advil (200mg) with Caffeine (100mg) is not commonly available but can likely be obtained when taking a 200mg ibuprofen tablet along with a cup of moderately strong coffee. 

Other common sources of caffeine, in addition to caffeine pills (100 mg is sufficient) and coffee (100 to 150 mg per cup with about 8 ounces, or a double espresso), include tea (75 mg per cup), herbal beverages cola (up to 40 mg per serving), energy drinks (about 80 mg per serving) or regular chocolate bars (up to 50 mg per bar), and caffeine tablets (up to 100 mg per tablet).

Some people may get good pain relief with a lower dose of Advil if this drug is combined with caffeine.

Can I mix paracetamol and caffeine?

No, you can not mix paracetamol and caffeine. Combining the analgesic paracetamol – present in most headache and fever medicines – with coffee can be harmful to health. The simultaneous ingestion of the drug not only with coffee, but with any beverage that contains caffeine, causes liver damage.

What was known was that combining paracetamol with alcohol is bad for the liver – especially since the drink potentiates the toxic effect of the drug. However, today the drug associated with caffeine has also been questioned.

The stimulant is actually added to many of the acetaminophen pain relievers available worldwide. Caffeine is believed to increase the pain-relieving power of acetaminophen. 

At the end of the day, what matters is that you shouldn’t stop taking paracetamol or ingesting products with caffeine. But you have to be careful with the combination of the two substances – especially if you drink alcohol.

Is drinking coffee while taking sleeping pills dangerous?

No, drinking coffee while taking sleeping pills is not dangerous. There are no studies that show a dangerous relationship between caffeine and the substances in sleeping pills. However, if these medications help to control anxiety, one of the effects of drinking coffee regularly is to increase anxiety.

Products that contain caffeine and medicines should not be combined whose active ingredient is theophylline (prescribed for asthma, bronchitis and chronic obstructive pulmonary disease).

This is because the substances overlap, increasing the drug’s toxicity and intensifying adverse effects such as tachycardia and agitation. The same can happen when mixing caffeine and the antibiotic ciprofloxacin, resulting in headache, insomnia and nausea.

However, there is no indication of the interaction of substances contained in sleeping pills with caffeine.

There are some drinks that can really help you get a good night’s sleep.

Foods and liquids that contain certain minerals, therapeutic herbs and tryptophan (an essential amino acid) stimulate the production of serotonin and melatonin, which are important hormones in the regulation of sleep.

Below is a list of drinks to help you sleep better at night:

  • Warm Milk
  • Almond Milk
  • Malted Milk
  • Valerian Tea
  • Chamomile Tea
  • Pure Coconut Water
  • Tart Cherry Juice

Can I take a pill with coffee?

Yes, you can take a pill with coffee. The medical literature does not say whether the combination of drugs with liquids other than water is capable of causing side effects or cutting the effectiveness of the drug. 

That’s why we believe it’s okay to consume most of the pills we use on a daily basis — to treat colds, flu and headaches, for example — with any type of drink. Usually, there is nothing to fear when ingesting a drug with juice, for example, even if the orientation is to take it on an empty stomach.

However, as it is a neutral drink, water is always the best alternative. Other liquids should only be used when there is no option — if you are on the street and cannot find a reliable source of drinking water, for example.

However, some medications can indeed interact with the substances contained in certain drinks, causing a change in the expected effect. 

In addition to impairing its effect, ingesting certain drugs with inappropriate liquid can trigger problems in the gastric mucosa, because due to the acidity of the drink, there is a risk of the tablet or capsule being dissolved in an unsuitable place. 

Every medication has its particularity and, when ingested with juices, teas and coffee, for example, a specific medication that must be absorbed in the intestine can end up being destroyed before, in the stomach.

Other FAQs about Coffee that you may be interested in.

Can I put coffee grounds in the garbage disposal?

Can I roast coffee using an airfryer?

Can I use coffee and lemon for weight loss?


In this short article, we answered the question “Can I mix Advil and coffee?”. In addition, we discussed possible interactions between caffeine and paracetamol and sleeping pills. Finally, we discussed if you can take a pill with coffee.