Dr. Priscilla Romina De Gregorio (PhD)
Biotech Scientist
Dr Priscilla De Gregorio PhD is a Biotechnologist with expertise in Food Microbiology, Probiotics, Nanotechnology, and Immunology. She writes and reviews content on these topics.
Dr Priscilla De Gregorio’s Highlights:
- Researcher at the National Consult of Scientific and Technology Research (CONICET) of Argentina.
- Four Post Doctorate focussed in Probiotics, Agricultural Microbiology, Nanotechnology, and Food Microbiology (in Argentina, Brazil, and Italy)
- PhD in Biological Sciences with a focus on Probiotics at the National University of Tucumán (UNT) of Argentina and a one-month internship at Hannover Medical School of Germany
- Bachelor in Biotechnology at the National University of Tucumán (UNT) of Argentina
Professional Experience
Dr Priscilla Romina De Gregorio obtained her PhD in Biological Sciences in 2015, and postdoctoral studies in 2017, both supported by grants from the National Council for Scientific and Technological Research (CONICET) of Argentina.
In 2017 Dr Priscilla Romina De Gregorio obtained a position at CONICET as a Researcher at the Reference Centre for Lactobacilli (CERELA). Throughout her PhD and as a researcher she developed research in the area of vaginal lactic acid bacteria with probiotic potential, using in vitro and in vivo experimental models.
Dr. Priscilla Romina De Gregorio has experience in different areas such as microbiology, immunology, and nanotechnology. She has conducted trials using eukaryotic cells and experimental mouse models to evaluate the mechanisms of action of lactobacilli and their metabolites. She was actively involved in two clinical studies with healthy women, evaluating the effects of lactobacilli with probiotic potential.
Dr Priscilla Romina De Gregorio is a co-author of numerous publications in international journals, 3 book chapters, and 1 patent, mostly related to probiotics. She has participated in several international scientific events and research projects, and in the licensing of probiotic strains of vaginal lactobacilli for an Argentinean company.
Dr Priscilla Romina De Gregorio has done doctoral and post-doctoral internships in different research groups in Germany, Brazil, Argentina, and Italy focused on Agricultural Microbiology, Nanotechnology, Food Microbiology, and Statistic Analyses.
Dr Priscilla Romina De Gregorio has already co-directed a master’s thesis and a graduate thesis. She also participates as a reviewer of scientific articles in different international journals.
Education
2009 – Bachelor in Biotechnology at the National University of Tucumán (UNT) of Argentina.
2015 – PhD in Biological Sciences at the National University of Tucumán (UNT) of Argentina with a scholarship from the National Consult of Scientific and Technology Research (CONICET) of Argentina and development in the Reference Center for Lactobacilli (CERELA – CONICET).
2014 – One-month internship at Hannover Medical School of Germany
2015 – 2017 Postdoctoral Scholarship of CONICET. Higher Institute for Biological Research (INSIBIO-CONICET-UNT). Laboratory of Pharmacy and Biotechnology. Tucuman, Argentina.
2015 – 2016 Post Doctorate (6 months) at Federal University of Rio Grande do Sul (UFRGS). Soil Microbiology Laboratory of the Soil Department of the Faculty of Agronomy. Company TECNANO, Porto Alegre, RS, Brazil.
2019 – Post Doctoral Scholarship (6 months) of Ministero degli Affari Esteri e della Cooperazione – Italian Government. Laboratory of Pharmacy and Biotechnology. Alma Mater Studiorum – Università di Bologna. Bologna, Italy.
2021 – 2023 Post Doctorate (19 months) at Graduate Program in Biotechnology (PPGBiotec) of the University of Vale do Taquari (Univates). Food Biotechnology Laboratory. Lajeado, RS, Brazil.
Articles
Juárez Tomás MS, Saralegui Duhart CI, De Gregorio PR, Vera Pingitore E, Nader-Macías ME. Urogenital pathogen inhibition and compatibility between vaginal Lactobacillus strains to be considered as probiotic candidates. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2011, 159, 399-406.
De Gregorio PR, Juarez Tomas MS, Santos V, Nader-Macias ME. Beneficial lactobacilli: effects on the vaginal tract in a murine experimental model. Antonie van Leeuwenhoek. 2012, 102, 569-580.
De Gregorio PR, Juarez Tomas MS, Leccese Terraf MC, Nader-Macias ME. In vitro and in vivo effects of beneficial vaginal lactobacilli on pathogens responsible for urogenital tract infections. Journal Medical Microbiology. 2014, 63, 685-696.
De Gregorio PR, Juarez Tomas MS, Leccese Terraf MC, Nader-Macias ME. Preventive effect of Lactobacillus reuteri CRL 1324 on Group B Streptococcus vaginal colonization in an experimental mouse model. Journal Applied Microbiology. 2015, 118, 1034-1047.
Juárez Tomás MS, De Gregorio PR, Leccese Terraf MC, Nader-Macías ME. Encapsulation and subsequent freeze-drying of Lactobacillus reuteri CRL 1324 for its potential inclusion in vaginal probiotic formulations. European Journal of Pharmaceutical Sciences. 2015, 79, 87-95.
De Gregorio PR, Juarez Tomas MS, Nader-Macias ME. Immunomodulation of Lactobacillus reuteri CRL 1324 on Group B Streptococcus vaginal colonization in a murine experimental model. American Journal of Reproductive Immunology. 2016, 75, 23-35.
Michavila G, Adler C, De Gregorio PR, Lami MJ, Caram di Santo MC, Zenoff A, de Cristobal RE, Vincent PA. Pseudomonas protegens CS1 from the lemon phyllosphere as a candidate for citrus canker biocontrol agent. Plant Biol (Stuttg). 2017, 19, 608-617.
De Gregorio PR, Michavila G, Ricciardi Muller L, de Souza Borges C, Pomares MF, Saccol de Sá EL, Pereira C, Vincent PA. Beneficial rhizobacteria immobilized in nanofibers for potential application as soybean seed bioinoculants. PLoS One. 2017, 12, e0176930.
De Gregorio PR, Salva S, Juárez Tomás MS, Nader-Macías MEF. Effects of exogenous sex hormones on mouse estrous cycle, vaginal microbiota and immune cells. Scand J Lab Anim Sci. 2018, 44 (3) ISSN 2002-0112.
De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019, 19, foz008.
De Gregorio PR, Maldonado NC, Vera Pingitore E, Leccese Terraf MC, Juárez Tomás MS, Silva de Ruiz C, Santos V, Wiese B, Bru E, Paiz MC, Reina MF, Schujman DE, Nader-Macías MEF. Intravaginal administration of gelatine capsules containing freeze-dried autochthonous lactobacilli: a double-blind, randomised clinical trial of safety. Beneficial microbes. Benef Microbes. 2020, 11, 5-17.
De Gregorio PR, Parolin C, Abruzzo A, Luppi B, Protti M, Mercolini L, Silva JA, Giordani B, Marangoni A, Nader-Macías MEF, Vitali B. Biosurfactant from vaginal Lactobacillus crispatus as a promising agent to prevent Candida adhesion. Microb Cell Fact. 2020, 19, 133. 2020.
Silva JA, De Gregorio PR, Rivero G, Abraham GA, Nader-Macías MEF. Immobilization of vaginal Lactobacillus in polymeric nanofibers for its incorporation in vaginal probiotic products. Eur J Pharm Sci, 2021, 156, 105563.
Abruzzo A, Giordani B, Parolin C, De Gregorio PR, Foschi C, Cerchiara T, Bigucci F, Vitali B, Luppi B. Lactobacillus crispatus BC1 Biosurfactant Delivered byd Hyalurosomes: An Advanced Strategy to Counteract Candida Biofilm. Antibiotics (Basel). 2021, 10, 33.
Parolin C, Croatti V, Laghi L, Giordani B, Tondi MR, De Gregorio PR, Foschi C, Vitali B. Lactobacillus Biofilms Influence Anti-Candida Activity. Front Microbiol, 2021, 12, 750368.
Nader-Macías MEF, De Gregorio PR, Silva JA. Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract. Pharmacol Res Perspect. 2021, 9, e00787.
Book Chapters
Nader-Macías MEF, De Gregorio PR. Probiotics and urogenital health. Probiotics Advanced Food and Health Applications. 2021, pp. 355-388.
De Gregorio PR, Gennari A, Nied CV, Volpato G, Volken de Souza CF. Low-lactose milk production using β-galactosidases. Enzymes Beyond Traditional Applications in Dairy Science and Technology, 2023, pp. 361–381.
De Gregorio PR, Gennari A, Nied CV, Volpato G, Volken de Souza CF. Production of oligosaccharides, a prebiotic from lactose, using β-galactosidase Enzymes Beyond Traditional Applications in Dairy Science and Technology, 2023, pp. 383-401.
Main Conferences
De Gregorio PR, Juárez Tomás MS, Nader-Macias MEF. Antimicrobial and aggregative properties of vaginal lactobacilli for their inclusion as active pharmaceutical ingredients (API) for pharmabiotic products. 2nd International Meeting of Pharmaceutical Sciences (RICIFA). Argentina. 2012.
De Gregorio PR, Juárez Tomás MS, Nader-Macías MEF. In vitro and in vivo effects of beneficial vaginal lactobacilli on pathogenic Streptococcus agalactiae. IV International Symposium on Lactic Acid Bacteria (SIBAL) Food, Health and Applications. Argentina. 2013.
De Gregorio PR, Juárez Tomás MS, Leccese Terraf C, Nader-Macías MEF. Dose-dependent preventive effect of Lactobacillus reuteri CRL 1324 on Group B Streptococcus vaginal colonization in an experimental mouse model. 2nd World Congress on Targeting Microbiota. France. 2014.
De Gregorio PR, Juárez Tomás MS, Nader-Macías MEF. Immunomodulation of Lactobacillus reuteri CRL1324 on group B Streptococcus vaginal colonization in a murine experimental model. SIBAL 2016 – V International Symposium on Lactic Acid Bacteria (SIBAL). Argentina. 2016.
De Gregorio PR. Preventive effect of probiotic lactobacilli on Streptococcus agalactiae vaginal colonization. In: 2nd International Symposium on Streptococcus agalactiae Disease (ISSAD). The Global Conference on Group B Streptococcus. Plenary Session. London, England. 2021.
You can view some of Dr De Gregorio’s work below and links to her professional profile.
Research Gate:https://www.researchgate.net/profile/Priscilla-De-Gregorio
Scopus: https://www.scopus.com/authid/detail.uri?authorId=54782313900
LinkedIn: https://www.linkedin.com/in/priscilla-romina-de-gregorio-a92482100/
